Analysis of Hemichannels and Gap Junctions: Application and Extension of the Passive Transmembrane Ion Transport Model

Electrical synaptic transmission is an essential form of interneuronal communication which mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to junctional channels. Each channel formed the docking hemichannel one cell with corresponding adjacent cell. To date, there has been a lack study models describe this structure in detail. In study, we demonstrate numerical simulations suggest passive transmembrane transport model, based on generality channels, also applies hemichannels non-junctional plasma membranes. On basis, established describes hemichannels' docking. We simulated homotypic heterotypic connexins, pannexins. Based results our theoretical discussed physiology junctions, including blockage hemichannels, voltage gating asymmetry delay electrical transmission, for are first comprehensively realized.